Novartis Foundation Symposium 244 Primary Author mixed material bibliography ENGLAND John Wiley & Sons, Ltd. 2002 en English

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Sry is active in the mouse for a very brief period in somatic cells of the genital ridge to initiate Sertoli cell di¡erentiation. SRY protein must act within the context of other gene products required for gonadal development and must itself act on one or more target genes that will ensure the further di¡erentiation and maintenance of Sertoli cells. Over the last few years several genes have been found that have important roles in gonadaldevelopmentandsexdetermination.Theseincludegenesencodingtranscription factors such as Lhx9, Wt1, Sf1, Dax1, Gata4, Dmrt1 and Sox9, and some involved in cell^cell signalling, including Amh, Wnt4 and Dhh. While more await discovery, it is now possible to start putting some of the known genes into pathways or networks. Sox9 probably occupies a critical role in mammals for both the initiation and maintenance of Sertoli cell di¡erentiation. Data will be presented that are consistent with SRY acting directly on Sox9 to ensure its up-regulation. SF1 is also central to gonadal di¡erentiation. Our results imply that it contributes to transcriptional activation of several relevant genes, not just those required for male development, including Sox9 and Amh, but also those that can have an antagonistic e¡ect on Sertoli cell di¡erentiation, such as Dax1. Progress in establishing other regulatory interactions willalso bediscussed. EBOOK GENETIC BIOLOGY NONE 0470843462 e-BOOK UPT Perpustakaan Instiper Yogyakarta THEGENETICSAND_BIOLOGYOFSEX_DETERMINATION.jpg.jpg 176 2018-09-19 14:00:48 2018-09-19 14:01:53 machine generated